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July 2015

OEHHA Lists Ethylene Glycol As A Proposition 65 Reproductive Toxicant

On June 19, 2015, the California Office of Environmental Health Hazard Assessment added ethylene glycol as a reproductive toxicant under Proposition 65 pursuant to the authoritative bodies listing mechanism. OEHHA based its listing on a 2004 monograph authored by the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR).  In that monograph, NTP-CERHR concluded that ethylene glycol causes developmental effects at high doses in rodents.  Significantly, OEHHA limited the listing to the oral ingestion route of exposure.  The warning requirement for this chemical will become effective June 19, 2016. A number of groups opposed the listing, and several groups submitted post-2004 studies demonstrating that no developmental effects are seen in rabbits (as opposed to rodents) even at high doses causing maternal toxicity. Further, significant physiological similarities between rabbit and human embryology strongly suggest that ethylene glycol would not cause developmental effects in humans either. Thus, the commenters argued …Read More